PPM1D 17:58677544-58741849

Forward strand gene: protein phosphatase, Mg2+/Mn2+ dependent 1D

Also known as: PP2C-DELTA, Wip1, ENSG00000170836

Function: Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of theseā€¦ Source: UniProt

DECIPHER holds 13 sequence variants in this gene, in 13 open-access patients