DYRK1A 21:38738092-38889753

Forward strand gene: dual specificity tyrosine phosphorylation regulated kinase 1A

Formerly known as: DYRK1, DYRK, MNBH

Also known as: ENSG00000157540

Function: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3. Source: UniProt

DECIPHER holds 35 sequence variants in this gene, in 35 open-access patients

Name RefSeq Location Size Type Protein Exons
DYRK1A-009 (ENST00000608928)
21:38738092-38792687
54.60 kb processed_transcript 2
DYRK1A-002 (ENST00000462274)
21:38739236-38858783
119.55 kb processed_transcript 5
DYRK1A-001 (ENST00000338785) NM_101395
21:38739879-38887680
147.80 kb protein_coding 584aa 13
DYRK1A-004 (ENST00000455097)
21:38739883-38845113
105.23 kb protein_coding 46aa 4
DYRK1A-005 (ENST00000426672)
21:38739883-38853007
113.12 kb protein_coding 131aa 5
DYRK1A-202 (ENST00000451934)
21:38791207-38878610
87.40 kb protein_coding 584aa 10
DYRK1A-201 (ENST00000321219)
21:38791207-38878651
87.44 kb protein_coding 541aa 11
DYRK1A-003 (ENST00000339659) NM_130436
21:38791207-38889753
98.55 kb protein_coding 754aa 11
DYRK1A-006 (ENST00000398960) NM_001396
NM_130438
21:38792602-38884889
92.29 kb canonical protein_coding 763aa 11
DYRK1A-007 (ENST00000498351)
21:38792627-38845017
52.39 kb processed_transcript 3
DYRK1A-008 (ENST00000398956)
21:38792677-38884257
91.58 kb protein_coding 529aa 10
DYRK1A-203 (ENST00000455387)
21:38861087-38884862
23.78 kb protein_coding 535aa 7

Use of consented DECIPHER data

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