DYRK1A 21:38738092-38889753

Forward strand gene: dual specificity tyrosine phosphorylation regulated kinase 1A

Formerly known as: DYRK1, DYRK, MNBH

Also known as: ENSG00000157540

Function: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3. Source: UniProt

DECIPHER holds 33 sequence variants in this gene, in 33 open-access patients

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