DYRK1A 21:38738092-38889753

Forward strand gene: dual specificity tyrosine phosphorylation regulated kinase 1A

Formerly known as: DYRK1, DYRK, MNBH

Also known as: ENSG00000157540

Function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity). Source: UniProt

DECIPHER holds 38 sequence variants in this gene, in 38 open-access patients

Name RefSeq Location Size Type Protein Exons
DYRK1A-009 (ENST00000608928)
21:38738092-38792687
54.60 kb processed_transcript 2
DYRK1A-002 (ENST00000462274)
21:38739236-38858783
119.55 kb processed_transcript 5
DYRK1A-001 (ENST00000338785) NM_101395
21:38739879-38887680
147.80 kb protein_coding 584aa 13
DYRK1A-004 (ENST00000455097)
21:38739883-38845113
105.23 kb protein_coding 46aa 4
DYRK1A-005 (ENST00000426672)
21:38739883-38853007
113.12 kb protein_coding 131aa 5
DYRK1A-202 (ENST00000451934)
21:38791207-38878610
87.40 kb protein_coding 584aa 10
DYRK1A-201 (ENST00000321219)
21:38791207-38878651
87.44 kb protein_coding 541aa 11
DYRK1A-003 (ENST00000339659) NM_130436
21:38791207-38889753
98.55 kb protein_coding 754aa 11
DYRK1A-006 (ENST00000398960) NM_001396
NM_130438
21:38792602-38884889
92.29 kb canonical protein_coding 763aa 11
DYRK1A-007 (ENST00000498351)
21:38792627-38845017
52.39 kb processed_transcript 3
DYRK1A-008 (ENST00000398956)
21:38792677-38884257
91.58 kb protein_coding 529aa 10
DYRK1A-203 (ENST00000455387)
21:38861087-38884862
23.78 kb protein_coding 535aa 7

Use of consented DECIPHER data

Anyone who proposes to publish material which uses data obtained from the DECIPHER database agrees to:

  • Acknowledge the DECIPHER Consortium; and
  • Contact the coordinator of the centre that entered the data on any individual who they wish to include in their report and offer appropriate agreed recognition of their contribution, which may include co-authorship if the magnitude of the contribution warrants it to at least one representative from the project/participating centre (possibly the member who submitted the patient data). This can be achieved by emailing a request to decipher@sanger.ac.uk

Access to bulk data may be obtained from DECIPHER and is subject to a Data Access Agreement, in which the user certifies that no attempt to identify individual patients will be undertaken. The same restrictions apply to the open-access data displayed on this website: no one is authorized to attempt to identify patients by any means.