Forward strand gene: cyclin dependent kinase 13
Formerly known as: CDC2L5
Also known as: ENSG00000065883, CHED, CDC2L, KIAA1791
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
DECIPHER holds 27 sequence variants in this gene, in 27 open-access patients
|CDK13-001 (ENST00000181839)|| NM_003718
|147.10 kb||canonical protein_coding||1512aa||14|