ADAM10 15:58887403-59042177

Reverse strand gene: ADAM metallopeptidase domain 10

Also known as: CD156C, HsT18717, MADM, kuz, ENSG00000137845

Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface … Source: UniProt

DECIPHER holds no open-access sequence variants in this gene