Mapping the clinical genome

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It's free and you don't need to log in

DECIPHER is used by the clinical community to share and compare phenotypic and genotypic data. The DECIPHER database contains data from 35845 patients who have given consent for broad data-sharing; DECIPHER also supports more limited sharing via consortia. Have a look at the numbers.

Anyone can browse publicly-available patient data on DECIPHER and request to be put in contact with the responsible clinician. Why? Because sharing benefits everyone.

Explore DECIPHER's genome browser Delve into the Human Phenotype Ontology Search all open-access DECIPHER data

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Be part of the sharing community

Projects affiliated to DECIPHER can deposit and share patients, variants, and phenotypes to invite collaboration and facilitate diagnosis. Once deposited, you can use DECIPHER to identify and prioritise potential matches, and you can request notifications as soon as new matches arrive.

As well as influencing individual patient outcomes, use of DECIPHER has contributed to over 1000 published articles since 2004. It's still free, and you are in control of what data to make public.

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Latest news

Reduced DECIPHER functionality period extended to 9 April

Due to an extended period of Ensembl downtime DECIPHER functionality may be affected until 9 April.

During this time the following DECIPHER resources may be affected:

  • Variant Effector Predictor (VEP) newly deposited variants.Variants will be annotated once the service is back online.
  • Conservation track in genome browser
  • dbSNP track in genome browser
  • PFam domain track in protein browser
  • 3D protein structures in protein browser

If you are using DECIPHER to interpret patient data during this time, please take into consideration the potential for reduced functionality.

Reduced DECIPHER functionality period extended to 3 April

Due to an extended period ofEnsembl downtime DECIPHER functionality may be affected until 3 April. The EMBL-EBI data centre will be migrating to a new physical location resulting in a period of reduction in availability and functionality in a number of Ensembl services.

Ensembl anticipate that services will start to come back online from the 3 April.

During this time the following DECIPHER resources may be affected:

  • Variant Effector Predictor (VEP) newly deposited variants.Variants will be annotated once the service is back online.
  • Conservation track in genome browser
  • dbSNP track in genome browser
  • PFam domain track in protein browser
  • 3D protein structures in protein browser

If you are using DECIPHER to interpret patient data during this time, please take into consideration the potential for reduced functionality.

Reduced DECIPHER functionality period extended: 10 – 25 March

Due to an extended period of Ensembl downtime (10-25 March) DECIPHER functionality may be affected from 10 March.The EMBL-EBI data centre will be migrating to a new physical location resulting in a period of reduction in availability and functionality in a number of Ensembl services.

Ensembl shut-down will begin on the 10th March and Ensembl anticipate that services will start to come back online from the 25th March.

During this time the following DECIPHER resources may be affected:

  • Variant Effector Predictor (VEP) newly deposited variants. Variants will be annotated once the service is back online.
  • Conservation track in genome browser
  • dbSNP track in genome browser
  • PFam domain track in protein browser
  • 3D protein structures in protein browser

If you are using DECIPHER to interpret patient data during this time, please take into consideration the potential for reduced functionality.

Reduced DECIPHER functionality 16 – 25 March

During March (16-25) some DECIPHER resources may not be available due to Ensembl downtime. The EMBL-EBI data centre will be migrating to a new physical location resulting in a period of reduction in availability and functionality in a number of Ensembl services.

During this time the following DECIPHER resources may be affected:

  • Variant Effector Predictor (VEP) newly deposited variants. Variants will be annotated once the service is back online.
  • Conservation track in genome browser
  • dbSNP track in genome browser
  • PFam domain track in protein browser
  • 3D protein structures in protein browser

Ensembl shut-down will begin on the 16th March and Ensembl anticipate that services will start to come back online from the 25th March.

If you are using DECIPHER to interpret patient data during this time, please take into consideration the potential for reduced functionality.

DECIPHER v9.31 Released

We released version 9.31 of DECIPHER on the 4th of December, 2019. This release includes minor changes and updates.

Wellcome Genome Campus courses in early 2020, including DECIPHER workshops

Clinical Genomics: Fundamentals of Variant Interpretation in Clinical Practice, is an advanced course suitable for both clinical geneticists (consultants and trainees) and clinical scientists delivering genetic healthcare. Application and bursary deadline 27 November 2019

Genomic Practice for Genetic Counsellors, is focused on the fundamental aspects of genomics and bioinformatics that underpin clinical practice with a particular emphasis on learning how to do variant interpretation. Application and bursary deadline 12 November 2019

DECIPHER v9.30 Released

We released version 9.30 of DECIPHER on the 31st of July, 2019. This release includes minor changes and updates.

Happy 15th Birthday DECIPHER

DECIPHER has been sharing rare disease patient records for 15 years. Currently ~30,000 patient variant records are shared openly on the website and to date >2,000 papers have used DECIPHER data; a testament to the importance of match-making in rare disease.

Read about finding a diagnosis for Eilidh and how DECIPHER has been fuelling rare disease research for 15 years.

 

DECIPHER v9.29 Released

We released version 9.29 of DECIPHER on the 22nd of May, 2019. Improvements include:

For more news about DECIPHER, click here.


Citing DECIPHER

DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources. Firth, H.V. et al (2009). Am.J.Hum.Genet 84, 524-533 (DOI: dx.doi.org/10/1016/j.ajhg.2009.03.010)

Authors who use data from the project must acknowledge DECIPHER using the following wording: "This study makes use of data generated by the DECIPHER community. A full list of centres who contributed to the generation of the data is available from http://decipher.sanger.ac.uk and via email from decipher@sanger.ac.uk. Funding for the project was provided by Wellcome."

Please see Citing DECIPHER for more information.