Mapping the clinical genome

It’s free and you don’t need to log in

DECIPHER is used by the clinical community to share and compare phenotypic and genotypic data. The DECIPHER database contains data from 21866 patients who have given consent for broad data-sharing; DECIPHER also supports more limited sharing via consortia. Have a look at the numbers.

Anyone can browse publicly-available patient data on DECIPHER and request to be put in contact with the responsible clinician. Why? Because sharing benefits everyone.

Explore DECIPHER’s genome browser Delve into the Human Phenotype Ontology Search all open-access DECIPHER data

Be part of the sharing community

Projects affiliated to DECIPHER can deposit and share patients, variants, and phenotypes to invite collaboration and facilitate diagnosis. Once deposited, you can use DECIPHER to identify and prioritise potential matches, and you can request notifications as soon as new matches arrive.

As well as influencing individual patient outcomes, use of DECIPHER has contributed to over 1000 published articles since 2004. It's still free, and you are in control of what data to make public.

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Latest news

DECIPHER v9.10 Released

We released version 9.10 of DECIPHER on the 10th of August, 2016. Improvements include:

DECIPHER Data Centre essential maintenance and website downtime

Due to essential Data Centre maintenance, the DECIPHER website will be unavailable from 17:00 BST on Friday 26th August 2016 BST until 11:00 BST on Tuesday 30th August 2016.
If you require further information please contact
We apologise for any inconvenience caused.

DECIPHER v9.9 Released

We released version 9.9 of DECIPHER on the 29th of June, 2016. Improvements include:

We’ve also been working in the background to prepare as the clinical community transitions to GRCh38.

DECIPHER v9.8 Released

We released version 9.8 of DECIPHER on the 25th of May, 2016. In addition to the new features below, please note that starting on 23rd June, we will be activating our “two-year hold” policy: unshared patients can be stored in DECIPHER for up to two years while preliminary pathogenicity assessments are made and informed consent is obtained and recorded for sharing variants. Once patient data is shared (either in a consortium or by consenting patients and variants for open-access release), patients will continue to be available indefinitely. Emails have already been sent out to those with unshared patient data entered before May 2014, and logged-in depositors can check the status of any patient (including how long they have left to obtain informed consent, if relevant) by visiting the patient page.

DECIPHER v9.7 released

We released version 9.7 of DECIPHER on the 27th of April, 2016. Our headline feature in this release is a 3D protein view: a visualisation of a deposited sequence variant on an experimentally determined protein structure (where available) from the Protein Data Bank (PDB). Where there are experimental structures available for a region that contains one or more open-access sequence variants, these can be seen from our gene pages (e.g. MECP2 or TBL1XR1). Then, click on one of the green bars on the protein domain view (representing PDB structures and their coverage) and choose “view” to see the variants we have in the region covered by the structure in the 3D view.

3D view of a MECP2 structure with mapped DECIPHER variants.

3D view of a MECP2 structure with mapped DECIPHER variants.

TBL1XR1 3D view

3D view of a TBL1XR1 structure with mapped DECIPHER variants.

We have also made many other under-the-hood changes to DECIPHER to allow us to roll out new features in future releases!

DECIPHER Video Tutorials

We are producing a series of video tutorials that showcase different aspects of the DECIPHER platform. Please subscribe to the DECIPHER YouTube channel to be kept updated on new tutorials as and when produced. We also welcome your suggestions for new tutorials.

For more news about DECIPHER, click here.


DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources. Firth, H.V. et al (2009). Am.J.Hum.Genet 84, 524-533 (DOI:

Authors who use data from the project must acknowledge DECIPHER using the following wording: "This study makes use of data generated by the DECIPHER community. A full list of centres who contributed to the generation of the data is available from and via email from Funding for the project was provided by the Wellcome Trust."

Please see Citing DECIPHER for more information.