It’s free and you don’t need to log in
DECIPHER is used by the clinical community to share and compare phenotypic and genotypic data. The DECIPHER database contains data from 19363 patients who have given consent for broad data-sharing; DECIPHER also supports more limited sharing via consortia. Have a look at the numbers.
Anyone can browse publicly-available patient data on DECIPHER and request to be put in contact with the responsible clinician. Why? Because sharing benefits everyone.
Be part of the sharing community
Projects affiliated to DECIPHER can deposit and share patients, variants, and phenotypes to invite collaboration and facilitate diagnosis. Once deposited, you can use DECIPHER to identify and prioritise potential matches, and you can request notifications as soon as new matches arrive.
As well as influencing individual patient outcomes, use of DECIPHER has contributed to over 1000 published articles since 2004. It's still free, and you are in control of what data to make public.
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DECIPHER v9.7 released
We released version 9.7 of DECIPHER on the 27th of April, 2016. Our headline feature in this release is a 3D protein view: a visualisation of a deposited sequence variant on an experimentally determined protein structure (where available) from the Protein Data Bank (PDB). Where there are experimental structures available for a region that contains one or more open-access sequence variants, these can be seen from our gene pages (e.g. MECP2 or TBL1XR1). Then, click on one of the green bars on the protein domain view (representing PDB structures and their coverage) and choose “view” to see the variants we have in the region covered by the structure in the 3D view.
We have also made many other under-the-hood changes to DECIPHER to allow us to roll out new features in future releases!
DECIPHER Video Tutorials
We are producing a series of video tutorials that showcase different aspects of the DECIPHER platform. Please subscribe to the DECIPHER YouTube channel to be kept updated on new tutorials as and when produced. We also welcome your suggestions for new tutorials.
For more news about DECIPHER, click here.
DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources. Firth, H.V. et al (2009). Am.J.Hum.Genet 84, 524-533 (DOI: dx.doi.org/10/1016/j.ajhg.2009.03.010)
Authors who use data from the project must acknowledge DECIPHER using the following wording: "This study makes use of data generated by the DECIPHER community. A full list of centres who contributed to the generation of the data is available from http://decipher.sanger.ac.uk and via email from firstname.lastname@example.org. Funding for the project was provided by the Wellcome Trust."
Please see Citing DECIPHER for more information.