It’s free and you don’t need to log in
DECIPHER is used by the clinical community to share and compare phenotypic and genotypic data. The DECIPHER database contains data from 18753 patients who have given consent for broad data-sharing; DECIPHER also supports more limited sharing via consortia. Have a look at the numbers.
Anyone can browse publicly-available patient data on DECIPHER and request to be put in contact with the responsible clinician. Why? Because sharing benefits everyone.
Be part of the sharing community
Projects affiliated to DECIPHER can deposit and share patients, variants, and phenotypes to invite collaboration and facilitate diagnosis. Once deposited, you can use DECIPHER to identify and prioritise potential matches, and you can request notifications as soon as new matches arrive.
As well as influencing individual patient outcomes, use of DECIPHER has contributed to over 700 published articles since 2004. It's still free, and you are in control of what data to make public.
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DECIPHER Video Tutorials
We are producing a series of video tutorials that showcase different aspects of the DECIPHER platform. Please subscribe to the DECIPHER YouTube channel to be kept updated on new tutorials as and when produced. We also welcome your suggestions for new tutorials.
DECIPHER v9.4 Released
Version 9.4 of DECIPHER was released on Wednesday 2nd December and includes the following new features:
- Phenotype Browser: We are very happy to present a brand new feature for visually exploring DECIPHER phenotypes using the Human Phenotype Ontology (HPO). The phenotype browser is an interactive tool that ties in with our search system to list patients that contain that specific phenotype or its descendant terms. A short video tutorial demonstrating this new tool can be seen here.
- Search: Sequence variants can now be found using Ensembl transcript identifiers in search. To find all patients in DECIPHER containing a variant in ENST00000346085, prefix your query with ‘transcript:’ for example: transcript:ENST00000346085.
- Genome Browser
- Automatic highlighting of selected variant makes it easier to identify a variant if there are multiple features on the same track.
- Track resize controls have improved visibility.
- Transcript and Sequence Conservation tracks now show amino acid 3-letter codes.
- New “Browse” location on top of page to explore the genome, phenotypes and syndromes as well as genes and gene disorders.
- Improvements to Bulk Upload template files to allow responsible contacts to be uploaded.
- Phenotype browser now available for Gene and Project Overview pages
- Update to GeneReviews Gene Disorders. Updates to reference data from various sources.
- Internal Matchmaker sends out email to watcher when a new match is available.
For more news about DECIPHER, click here.
DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources. Firth, H.V. et al (2009). Am.J.Hum.Genet 84, 524-533 (DOI: dx.doi.org/10/1016/j.ajhg.2009.03.010)
Authors who use data from the project must acknowledge DECIPHER using the following wording: "This study makes use of data generated by the DECIPHER community. A full list of centres who contributed to the generation of the data is available from http://decipher.sanger.ac.uk and via email from email@example.com. Funding for the project was provided by the Wellcome Trust."
Please see Citing DECIPHER for more information.